Application
Western blot analysis of ZBP1 expression in non-transfected: (A) and mouse ZBP1 transfected: (B) 293T whole cell lysates and mouse liver (C) and rat liver (D) tissue extracts.Application
Western blot analysis of ZBP1 expression in non-transfected: (A) and mouse ZBP1 transfected: (B) 293T whole cell lysates.| Product Name | ZBP1 Antibody (R-259) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 12-270 mapping at the N-terminus of ZBP1 of rat origin |
| Modification Notes | Left-handed Z-DNA is a higher energy form of the double helix. Proteins containing Za domains share a remarkable ability to bind specifically to Z-DNA and/or Z-RNA. ZBP1 (Z-DNA binding protein 1), also designated DLM-1, is a 429 amino acid protein that harbors two copies of the Za domain containing the Za motif at its N-terminus. ZBP1 is involved in host responses against cellular stresses, including tumorigenesis and viral infection. It is highly expressed in lymphatic tissues including leukocytes, lymph node, tonsil, bone marrow, spleen and, to a lesser extent, in thymus, lung and liver. There are five known isoforms of human ZBP1. The ZBP1 protein shares 47% and 46% sequence identity with the mouse and rat homologs, respectively. The mouse, rat, and human ZBP1 proteins all contain four conserved regions, two of which are homologous to the Z-DNA binding domains Za and Zb of the RNA editing enzyme ADAR1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ZBP1 of rat and, to a lesser extent, mouse origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 12-270 mapping at the N-terminus of ZBP1 of rat origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 12-270 mapping at the N-terminus of ZBP1 of rat origin |
| Entrez Gene | 58203 |
|---|
Application
Western blot analysis of ZBP1 expression in non-transfected: (A) and mouse ZBP1 transfected: (B) 293T whole cell lysates and mouse liver (C) and rat liver (D) tissue extracts.
Application
Western blot analysis of ZBP1 expression in non-transfected: (A) and mouse ZBP1 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of ZBP1 of rat and, to a lesser extent, mouse origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
