| Product Name | Codanin-1 Antibody (H-301) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 780-1080 mapping near the C-terminus of Codanin-1 of human origin |
| Modification Notes | The congenital dyserythropoietic anemias (CDAs) are an uncommon and heterogeneous group of disorders that are characterized by markedly ineffective erythropoiesis and, usually, striking dysplastic changes in erythroblasts. Con-genital dyserythropoietic anemia type 1 (CDA1) is a rare autosomal recessive disorder with ineffective erythropoiesis, characteristic morphological abnormalities of erythroblasts and iron overloading. CDA1 is caused by mutations in the CDAN1 gene, which maps to chromosome 15q15.2 and encodes the 1,227 amino acid protein Codanin-1. Codanin-1 has a 150 residue N-terminal domain with sequence similarity to collagens and two shorter segments that show weak similarities to the microtubule-associated proteins synapsin and MAP-1B (neuraxin). Research indicates that Codanin-1 may be involved in nuclear envelope integrity, conceivably related to microtubule attachments. Skeletal anomalism has been associated with mutations of CDAN1, indicating that Codanin-1 may play a role in the development of the skeleton. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Codanin-1 of mouse, human and, to a lesser extent, rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 780-1080 mapping near the C-terminus of Codanin-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 780-1080 mapping near the C-terminus of Codanin-1 of human origin |
| Entrez Gene | 146059 |
|---|
| Application Notes | recommended for detection of Codanin-1 of mouse, human and, to a lesser extent, rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
