Application
Western blot analysis of SNX17 expression in non-transfected: (A) and human SNX17 transfected: (B) 293T whole cell lysates.| Product Name | SNX17 Antibody (H-201) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 270-470 mapping at the C-terminus of SNX17 of human origin |
| Modification Notes | Sorting nexin (SNX) proteins are members of a large family of hydrophilic proteins that interact with a variety of receptor types, are involved in intracellular trafficking and contain a characteristic phox homology (PX) domain. SNX17, which demonstrates ubiquitous expression, contains a PX domain that shares 28% sequence identity with the PX domain of SNX1, as well as a B41 (FERM) domain. The SNX17 gene maps to chromosome 2 and is part of the cellular sorting machinery that regulates cell surface levels of LRP (lipoprotein receptor-related protein) by promoting its recycling. While the PX domain of SNX17 interacts with phosphatidylinositol-3-phosphate for membrane association, the FERM domain and the carboxyl-terminal region aid in LRP binding. Research indicates that SNX17 is localized to the limiting membrane and recycling tubules of early endosomes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SNX17 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 270-470 mapping at the C-terminus of SNX17 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 270-470 mapping at the C-terminus of SNX17 of human origin |
| Entrez Gene | 9784 |
|---|
Application
Western blot analysis of SNX17 expression in non-transfected: (A) and human SNX17 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of SNX17 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
