| Modification Notes |
The process of homologous recombination is a major DNA repair pathway that operates on DNA double-strand breaks to promote error-free repair. Central to the process of homologous recombination are the Rad52 group genes (RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57, RAD59, MRE11, and XRS2), most of which were identified by their requirement for the repair of ionizing-radiation-induced DNA damage in Saccharomyces cerevisiae. The Saccharomyces cerevisiae RAD51, RAD55, and RAD57 genes, required for genetic recombination and DNA double-strand-break repair, encode proteins homologous to one another and to the Escherichia coli RecA protein (sung97). The RAD55 and RAD57 encoded products exist as a stable heterodimer. |