| Modification Notes |
COQ10A, Coenzyme Q10, is a 247 amino acid protein encoded by the human gene COQ10A. COQ10A is a mitochondrial protein that belongs to the COQ10 family. COQ10A is an essential biological cofactor which increases brain mitochondrial concentration and exerts neuroprotective effects. Plasma COQ10A levels decrease in patients with advanced chronic heart failure (CHF) while COQ10A levels in hyperthyroid patients are found among the lowest detected in human diseases. Likewise, COQ10A is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. It is believed that secretion of adrenal hormones is in some way related to COQ10A levels, both in augmented and reduced conditions. However, since thyroid hormones have an important role in modulating COQ10A levels and metabolism, when coexistent, thyroid deficiency seems to play a prevalent role in comparison with adrenal deficiency. |
