The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins that acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TMTC3 (transmembrane and tetratricopeptide repeat containing 3), also known as SMILE, is a 915 amino acid multi-pass membrane protein belonging to the TMTC family and contains ten TPR repeats. Existing as two alternatively spliced isoforms, TMTC3 is encoded by a gene located on human chromosome 12q21.32. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of TMTC3 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with TMTC1, TMTC2 or TMTC4
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope mapping at the C-terminus of TMTC3 of human origin
Tissue Specificity
epitope mapping at the C-terminus of TMTC3 of human origin