| Product Name | ADAM3 Antibody (M-135) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 461-595 mapping within an internal region of ADAM3 of mouse origin |
| Modification Notes | ADAMs (a disintegrin and metalloproteinase domain), also known as MDCs (metalloproteinase, disintegrin, and cysteine-rich domain) or cellular disintegrins, are a family of proteins that are expressed in numerous different tissues. They catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAMs are membrane-anchored, glycosylated, Zn2+ dependent proteases and there are over 30 different members in the family with many diverse functions. ADAM3, also called cyritestin, is exclusively expressed on the surface of sperm. In the early development of sperm, ADAM3 forms a complex with ADAM2. Disruption of this complex can impair the function and structure of ADAM3. ADAM3 plays a significant role in sperm-oocyte binding. Sperm lacking functional ADAM3 cannot bind to the zona pellucida and fertilization cannot take place. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ADAM3 of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 461-595 mapping within an internal region of ADAM3 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 461-595 mapping within an internal region of ADAM3 of mouse origin |
| Entrez Gene | 11497 |
|---|
| Application Notes | recommended for detection of ADAM3 of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
