Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human bronchus tissue showing cytoplasmic staining of respiratory epithelial cells.Application
Western blot analysis of IFN-γRβ expression in human PBL whole cell lysate.| Product Name | IFN-γRβ Antibody (C-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of IFN-γRβ of human origin |
| Modification Notes | IFN-© induces a variety of biological responses, such as antiviral, antiproliferative and immunomodulatory activity in sensitive cells (1–3). Activation of the IFN-© receptor (IFN-©R) leads to autophosphorylation of the Janus kinases JAK1 and JAK2, and the nuclear translocation of the transcription factors Stat1å p91 and Stat1∫ p84 (3–6). The IFN-©R is composed of at least two chains, designated IFN-©Rå and IFN-©R∫, respectively (7–9). Although expression of IFN-©Rå is sufficient for ligand binding, it alone does not confer responsiveness to IFN-© (7). Concomitant expression of IFN-©Rå and IFN-©R∫ is required for transcriptional activation of IFN-©-inducible genes (7,8). The IFN-©R∫ chain, also called AF-1, is 332 and 337 amino acids in length in mouse and human, respectively, and may represent the signal transducing component of the IFN-©R (7,8). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of IFN-γRβ of human origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of IFN-&gamma R&beta of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of IFN-γRβ of human origin |
| Entrez Gene | 3460 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human bronchus tissue showing cytoplasmic staining of respiratory epithelial cells.
Application
Western blot analysis of IFN-γRβ expression in human PBL whole cell lysate.| Application Notes | recommended for detection of IFN-γRβ of human origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
