Application
Western blot analysis of Deltex-2 expression in non-transfected: (A) and human Deltex-2 transfected: (B) 293 whole cell lysates.Application
Western blot analysis of Deltex-2 expression in Hep G2 whole cell lysate.Application
Western blot analysis of Deltex-2 expression in non-transfected: (A) and human Deltex-2 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of Deltex-2 expression in non-transfected 293T: (A), human Deltex-2 transfected 293T: (B) and Hep G2 (C) whole cell lysates.| Product Name | Deltex-2 Antibody (H-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against Deltex-2 of human origin |
| Modification Notes | The Deltex family of proteins (Deltex-1, 2, 3 and 4) are mammalian homologs of Drosophila Deltex. This family contains two WWE domains and a C-terminal RING-finger domain, which are regions that are frequently found in E3 ubiquitin ligases. Deltex-2, also known as hDTX2 or RING-finger protein 58, is a 622 amino acid protein that plays a regulatory role in the Notch signaling pathway. Like Deltex-1, Deltex-2 interacts with an intracellular domain of Notch. Localized to the cytoplasm with partial localization to the nucleus, Deltex-2 has been shown to function as a ubiquitin ligase protein in vitro, possibly explaining the mechanism by which it positively and negatively regulates Notch. Deltex-2 is highly expressed in thymus and pancreas where it exists as either a homomultimer or a heteromultimer with other Deltex family members. Two isoforms of Deltex-2 are expressed due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of Deltex-2 of human, canine and zebrafish origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against Deltex-2 of human origin |
|---|---|
| Tissue Specificity | raised against Deltex-2 of human origin |
| Entrez Gene | 113878 |
|---|
Application
Western blot analysis of Deltex-2 expression in non-transfected: (A) and human Deltex-2 transfected: (B) 293 whole cell lysates.
Application
Western blot analysis of Deltex-2 expression in Hep G2 whole cell lysate.
Application
Western blot analysis of Deltex-2 expression in non-transfected: (A) and human Deltex-2 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of Deltex-2 expression in non-transfected 293T: (A), human Deltex-2 transfected 293T: (B) and Hep G2 (C) whole cell lysates.| Application Notes | recommended for detection of Deltex-2 of human, canine and zebrafish origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
