Application
Western blot analysis of ALDH3A2 expression in non-transfected: (A) and mouse ALDH3A2 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of ALDH3A2 expression in non-transfected: (A) and human ALDH3A2 transfected: (B) 293T whole cell lysates.Application
Western blot analysis of ALDH3A2 expression in non-transfected: (A) and human ALDH3A2 transfected: (B) 293T whole cell lysates.| Product Name | ALDH3A2 Antibody (H-76) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH3A2 (aldehyde dehydrogenase 3 family, member A2), also known as SLS, FALDH or ALDH10, is a 485 amino acid single-pass membrane protein that localizes to the cytoplasmic side of the endoplasmic reticulum and belongs to the aldehyde dehydrogenase family. Expressed in a variety of tissues, including liver, heart, lung, brain, kidney and placenta, ALDH3A2 catalyzes the NAD+-dependent oxidation of long-chain aliphatic aldehydes to fatty acids, a process that is necessary for detoxification and lipid metabolism. Defects in the gene encoding ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS), an autosomal recessive neurocutaneous disorder characterized by severe mental retardation, seizures and speech defects. Multiple isoforms of ALDH3A2 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ALDH3A2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 28-103 mapping within a cytoplasmic domain of ALDH3A2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 28-103 mapping within a cytoplasmic domain of ALDH3A2 of human origin |
| Entrez Gene | 224 |
|---|
Application
Western blot analysis of ALDH3A2 expression in non-transfected: (A) and mouse ALDH3A2 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of ALDH3A2 expression in non-transfected: (A) and human ALDH3A2 transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of ALDH3A2 expression in non-transfected: (A) and human ALDH3A2 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of ALDH3A2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
