Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing nuclear and cytoplasmic staining of exocrine glandular cells and Islets of Langerhans.Application
Western blot analysis of Transketolase expression in rat kidney tissue extract.Application
Western blot analysis of Transketolase expression in non-transfected 293T: (A), human Transketolase transfected 293T: (B) and HeLa (C) whole cell lysates.| Product Name | Transketolase Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 261-310 mapping within an internal region of Transketolase of human origin |
| Modification Notes | Transketolase (TK or TKT), a member of the Transketolase family, is a multifunctional protein that plays a role in diabetes, cancer, Alzheimer’s disease and Wernicke-Korsakoff’s syndrome, a latent genetic neurological disorder. Transketolase is also important for the prevention of hyperglycemia-induced vascular damage. Transketolase is a crucial protein in the pentose phosphate pathway (PPP), where it catalyzes several reactions. In combination with Transaldolase, Transketolase functions as a link between glycolysis and the non-oxidative part of the PPP, allowing the cell to adapt to varying metabolic conditions in response to environmental changes. Transketolase activity is detected in small intestine epithelia, liver parenchyma, tongue, cornea and trachea. It is also expressed in the proximal tubules of kidney and in ganglion cells in medulla of the adrenal gland. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of Transketolase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 261-310 mapping within an internal region of Transketolase of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 261-310 mapping within an internal region of Transketolase of human origin |
| Entrez Gene | 7086 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing nuclear and cytoplasmic staining of exocrine glandular cells and Islets of Langerhans.
Application
Western blot analysis of Transketolase expression in rat kidney tissue extract.
Application
Western blot analysis of Transketolase expression in non-transfected 293T: (A), human Transketolase transfected 293T: (B) and HeLa (C) whole cell lysates.| Application Notes | recommended for detection of Transketolase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
