| Product Name | CYFIP1/2 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 954-1253 mapping at the C-terminus of CYFIP1 of human origin |
| Modification Notes | CYFIP1 (cytoplasmic FMR1 interacting protein 1) and CYFIP2 (cytoplasmic FMR1 interacting protein 2) are cytoplasmic proteins belonging to the CYFIP family. Both proteins bind GTP-bound Rac 1 to release FRM1 in its active state, which is thought to regulate mRNA translation of neural cytoskeletal proteins. A loss of CYFIP1 and CYFIP2 leads to mutant neurons with defective axonal growth and motor function. Also designated specifically Rac1-associated protein 1 (sra-1) or p140sra-1, CYFIP1 contains 1,253 amino acids and is a component of the WAVE2 complex. CYFIP1 is encoded by a gene that maps to human chromosome 15q11.2 and exists as three alternatively spliced isoforms. CYFIP2, also known as p53-inducible protein 121, contains 1,278 amino acids and plays a role in p53-dependent apoptosis. Existing as two alternatively spliced isoforms, CYFIP2 is a component of the WAVE1 complex and is encoded by a gene located on human chromosome 5q33.3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CYFIP1 and CYFIP2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 954-1253 mapping at the C-terminus of CYFIP1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 954-1253 mapping at the C-terminus of CYFIP1 of human origin |
| Application Notes | recommended for detection of CYFIP1 and CYFIP2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
