| Product Name | ACD Antibody (M-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 117-416 mapping at the C-terminus of ACD of mouse origin |
| Modification Notes | ACD (adrenocortical dysplasia homolog), also known as PIP1, PTOP, TPP1 or TINT1 is a 544 amino acid human homolog of the mouse Acd protein and is one of six components in the telosome/shelterin complex; a complex involved in shaping and guarding telomeres. ACD is essential for the proper assembly and stabilization of the telomere-associated complex and is able to interact directly with POT1 (protection of telomeres 1) and TRF1 (telomeric repeat binding factor 1), two additional members of the multi-protein complex. Localized to the nucleus, ACD helps to control telomere length and elongation by mediating telomerase activity and telomerase access to DNA. Through its ability to control and maintain telomere growth, ACD is thought to be involved in organogenesis. Two isoforms of ACD are expressed due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ACD of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 117-416 mapping at the C-terminus of ACD of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 117-416 mapping at the C-terminus of ACD of mouse origin |
| Application Notes | recommended for detection of ACD of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
