| Product Name | LARGE Antibody (H-164) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 137-300 mapping within an internal region of LARGE of human origin |
| Modification Notes | Glycosyltransferase-like protein LARGE, also designated acetylglucosaminyl-transferase-like protein, belongs to the glycosyltransferase 8 family. This ubiquitously expressed protein is a type II membrane protein. Although it is widely expressed, highest levels of detection are in heart, brain and skeletal muscle. LARGE carries out the synthesis of glycosphingolipid and glycoprotein sugar chains and is part of the repeated disaccharide unit addition. It may also be important in the hyperglycosylation of å-dystroglycan. This interaction of LARGE with dystroglycan is crucial for the biosynthetic pathway to create functional dystroglycan. Loss of functional dystroglycan can result in muscle degeneration. The gene encoding for LARGE maps to chromosome 22q12.3, and defects in this gene can cause congenital muscular dystrophy, an autosomal recessive disorder. LARGE co-localizes with GM130, a Golgi marker. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LARGE, and to a lesser extent LARGE2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 137-300 mapping within an internal region of LARGE of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 137-300 mapping within an internal region of LARGE of human origin |
| Entrez Gene | 9215 |
|---|
| Application Notes | recommended for detection of LARGE, and to a lesser extent LARGE2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
