Application
Immunofluorescence staining of normal mouse heart frozen section showing membrane staining.| Product Name | AChRε Antibody (H-160) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 334-441 of AChRε of human origin |
| Modification Notes | Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChRé, also known as CMS1D, CMS1E, CMS2A, FCCMS, SCCMS or CHRNE, is a 493 amino acid multi-pass membrane protein associated with congenital myasthenic syndrome slow-channel type (SCCMS), congenital myasthenic syndrome fast-channel type (FCCMS) and congenital myasthenic syndrome with acetylcholine receptor deficiency. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of AChRε of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 334-441 of AChR&epsilon of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 334-441 of AChRε of human origin |
| Entrez Gene | 1145 |
|---|
Application
Immunofluorescence staining of normal mouse heart frozen section showing membrane staining.| Application Notes | recommended for detection of AChRε of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
