| Product Name | Tachykinin Antibody (FL-129) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-129 representing full length tachykinin 1 of human origin |
| Modification Notes | The tachykinin family consists of amidated neuropeptides that share a carboxy-terminal sequence (Phe-X-Gly-Leu-Met-NH2). Preprotachykinin I, also designated protachykinin 1 precursor (PPT), is a common precursor of tachykinins. Preprotachykinin I alternately splices to form various isoforms. These isoforms include Substance P, Neurokinin A (NKA, Substance K, Neuromedin L), Neurokinin B, Neuropeptide K (NPK), Neuropeptide © and C-terminal flanking peptide. Substance P is expressesed primarily in the small diameter primary sensory fibers of the peripheral nervous system, and in the superficial dorsal horn of the spinal cord, the substantia nigra and the medial amygdaloid nucleus of the central nervous system. Tachykinin peptides have many plieotropic functions, including neurotransmission, immune/ hematopoietic modulation, angiogenesis and mitogenesis. Preprotachykinin I has been implicated in breast cancer and bone marrow metastasis. Substance P plays a role in depression. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of tachykinin precursor and all active peptides of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-129 representing full length tachykinin 1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-129 representing full length tachykinin 1 of human origin |
| Entrez Gene | 6863 |
|---|
| Application Notes | recommended for detection of tachykinin precursor and all active peptides of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
