Application
Western blot analysis of Trk C expression in EOC 20 whole cell lysate.| Product Name | Trk C Antibody (798) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of Trk C of porcine origin |
| Modification Notes | The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on Tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, is mainly expressed in nervous tissue, and is a functional receptor for NT-3. Four forms of Trk C are produced by alternative splicing. Isoform A is full length Trk C, isoform B differs from A between amino acids 529 to 612 and is missing amino acids 613 to 839. Trk C, isoform C is missing amino acids 712 to 725 and isoform D is missing amino acids 402 to 410. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Trk C gp145 isoforms A, C and D of mouse, rat, human and porcine origin by WB, IP, IF and ELISA non-reactive with isoform B also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of Trk C of porcine origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of Trk C of porcine origin |
| Entrez Gene | 4916 |
|---|
Application
Western blot analysis of Trk C expression in EOC 20 whole cell lysate.| Application Notes | recommended for detection of Trk C gp145 isoforms A, C and D of mouse, rat, human and porcine origin by WB, IP, IF and ELISA non-reactive with isoform B also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
