Application
Western blot analysis of G6PT expression in Hep G2 (A), HeLa (B), KNRK (C) and Caki-1 (D) whole cell lysates and rat liver (E) and mouse kidney (F) tissue extracts.| Product Name | G6PT Antibody (E-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of G6PT of human origin |
| Modification Notes | G6PT (glucose-6-phosphate translocase), also known as G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, TRG19 or SLC37A4 (solute carrier family 37, member 4), is a 429 amino acid endoplasmic reticulum multi-pass membrane protein belonging to the SLC37A family (also known as SLC37A sugar transporter family) of the major facilitator superfamily. Highly expressed in liver and kidney, G6PT is involved in the transport of glucose-6-phosphate (G6P) from the cytoplasm to the lumen of the endoplasmic reticulum. G6PT plays a critical role in glycogenolysis and gluconeogenesis, which are metabolic pathways involved in the regulation of blood glucose levels. G6PT also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutation in the gene encoding G6PT causes glycogen storage disease type 1B (GSD1B), a disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of G6PT isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of G6PT of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of G6PT of human origin |
| Entrez Gene | 2542 |
|---|
Application
Western blot analysis of G6PT expression in Hep G2 (A), HeLa (B), KNRK (C) and Caki-1 (D) whole cell lysates and rat liver (E) and mouse kidney (F) tissue extracts.| Application Notes | recommended for detection of G6PT isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
