Application
Western blot analysis of MCF2L2 expression in MIA PaCa-2 (A), IMR-32 (B), SH-SY5Y (C) and NTERA-2 cl.D1 (D) whole cell lysates.| Product Name | MCF2L2 Antibody (N-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the N-terminus of MCF2L2 of human origin |
| Modification Notes | The Ras superfamily of GTPases, which can be subdivided into the Ras, Rho/Rac, Sar, Rab, ARF and Ran subfamilies, controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. The Ras superfamily of GTPases function as regulated switches that toggle between a biologically active GTP-bound and an inactive GDP-bound form. This activation is catalyzed by guanine nucleotide exchange factors (GEFs). MCF2L2 (MCF.2 cell line derived transforming sequence-like 2), also known as DRG, is a 1,114 amino acid protein that contains one spectrin repeat, one PH domain, one DH domain and one CRAL-TRIO domain. Expressed at high levels in brain and also present in testis and pancreas, MCF2L2 is thought to function as a GEF, catalyzing the activation of target GTPases. Variations in the gene encoding MCF2L2 may be associated with an increased susceptibility to type 2 diabetes. Multiple isoforms of MCF2L2 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MCF2L2 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the N-terminus of MCF2L2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the N-terminus of MCF2L2 of human origin |
| Entrez Gene | 23101 |
|---|
Application
Western blot analysis of MCF2L2 expression in MIA PaCa-2 (A), IMR-32 (B), SH-SY5Y (C) and NTERA-2 cl.D1 (D) whole cell lysates.| Application Notes | recommended for detection of MCF2L2 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
