Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing membrane staining of cortical cells (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Western blot analysis of KCNQ1 expression in Sol8 whole cell lysate (A) and mouse heart (B), mouse kidney (C) and rat heart (D) tissue extracts.Application
Western blot analysis of human recombinant KCNQ1 fusion protein.| Product Name | KCNQ1 Antibody (H-130) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 547-676 mapping at the C-terminus of KCNQ1 of human origin |
| Modification Notes | Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an å subunit KCNQ1 and a ∫ subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of KCNQ1 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 547-676 mapping at the C-terminus of KCNQ1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 547-676 mapping at the C-terminus of KCNQ1 of human origin |
| Entrez Gene | 3784 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing membrane staining of cortical cells (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Western blot analysis of KCNQ1 expression in Sol8 whole cell lysate (A) and mouse heart (B), mouse kidney (C) and rat heart (D) tissue extracts.
Application
Western blot analysis of human recombinant KCNQ1 fusion protein.| Application Notes | recommended for detection of KCNQ1 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
