Application
Western blot analysis of MMS19 expression in HeLa (A), Jurkat (B), K-562 (C) and Ramos (D) nuclear extracts and COLO 320DM (E) whole cell lysate.| Product Name | MMS19 Antibody (S-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of MMS19 of human origin |
| Modification Notes | MMS19 (MMS19 nucleotide excision repair homolog), also known as MET18, is a 1,030 amino acid nuclear protein containing seven HEAT repeats that belongs to the MET18/MMS19 family. Via its interactions with TFIIH p80 and TFIIH p89 helicases, MMS19 plays a role in nucleotide excision repair (NER) and RNA polymerase II (Pol II) transcription. MMS19 may also function as a transcriptional coactivator of estrogen receptor. While ubiquitously expressed, highest levels of MMS19 have been found in testis. At least five distinct MMS19 protein isoforms exist, which are produced by alternative splicing events. The gene encoding MMS19 maps to human chromosome 10q24.1, and is associated with the risk of pancreatic cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MMS19 isoforms 1, 2, 4 and 5 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with MMS19 isoform 3: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of MMS19 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of MMS19 of human origin |
| Entrez Gene | 64210 |
|---|
Application
Western blot analysis of MMS19 expression in HeLa (A), Jurkat (B), K-562 (C) and Ramos (D) nuclear extracts and COLO 320DM (E) whole cell lysate.| Application Notes | recommended for detection of MMS19 isoforms 1, 2, 4 and 5 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with MMS19 isoform 3: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
