Application
Western blot analysis of SIGIRR expression in A549 whole cell lysate.Application
Western blot analysis of SIGIRR expression in HeLa whole cell lysate.| Product Name | SIGIRR Antibody (H-186) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 225-410 mapping within a C-terminal cytoplasmic domain of SIGIRR of human origin |
| Modification Notes | Single Ig IL-1-related receptor SIGIRR, also designated single immunoglobulin domain-containing IL-1R-related protein or Toll/interleukin-1 receptor 8 (TIR8), is a member of the interleukin-1 receptor family. SIGIRR acts as a negative regulator of the IL-1R and Toll-like receptor signaling pathways and reduces the recruitment of certain components to the TLR4 receptor. Subsequently, SIGIRR confers resistance to P. aeruginosa corneal infection. SIGIRR can form complexes with IL-1R1, MYD-88, IRAK-1 and TRAF-6 upon IL-1 stimulation and TLR4 after LPS stimulation. It is a single-pass type III membrane protein that is mainly expressed in kidney, lung and gut. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SIGIRR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 225-410 mapping within a C-terminal cytoplasmic domain of SIGIRR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 225-410 mapping within a C-terminal cytoplasmic domain of SIGIRR of human origin |
| Entrez Gene | 59307 |
|---|
Application
Western blot analysis of SIGIRR expression in A549 whole cell lysate.
Application
Western blot analysis of SIGIRR expression in HeLa whole cell lysate.| Application Notes | recommended for detection of SIGIRR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
