Application
Western blot analysis of EXOSC3 expression in c4 whole cell lysate (A) and mouse kidney tissue extract (B).Application
Immunofluorescence staining of formalin-fixed Hep G2 cells showing nucleolar localization.| Product Name | EXOSC3 Antibody (FL-275) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-275 representing full length EXOSC3 of human origin |
| Modification Notes | The exosome is a multisubunit complex of 3’ to 5’ exoribonucleases. It is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements in their untranslated 3’ region. EXOSC3 (exosome component 3), also known as p10, CGI-102, RRP40 (Ribosomal RNA-processing protein 40), Rrp40p or hRrp40p, is a component of the exosome multienzyme ribonuclease complex. Localizing to the cytoplasm and nucleolus, EXOSC3 contains a putative S1 RNA-binding domain and is capable of binding RNA. EXOSC3 is a component of the top cap of the exosome and is essential for exosome stability. In addition, EXOSC3 is required for the processing of the 7S pre-RNA to the mature 5.8S rRNA. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of EXOSC3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-275 representing full length EXOSC3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-275 representing full length EXOSC3 of human origin |
| Entrez Gene | 51010 |
|---|
Application
Western blot analysis of EXOSC3 expression in c4 whole cell lysate (A) and mouse kidney tissue extract (B).
Application
Immunofluorescence staining of formalin-fixed Hep G2 cells showing nucleolar localization.| Application Notes | recommended for detection of EXOSC3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
