| Product Name | NIPBL Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of NIPBL of human origin |
| Modification Notes | NIPBL (Nipped-B-like protein), also known as IDN3, Delangin or CDLS, is a 2,804 amino acid nuclear protein that is the mammalian homolog of the Drosophila Nipped-B gene product, a protein that plays a role in developmental regulation by facilitating the communication between promoters and transcriptional enhancers. Widely expressed with particularly high levels present in skeletal muscle, heart, liver and kidney, NIPBL contains five HEAT repeats and interacts with HP1å, possibly playing a role in sister chromatid adhesion and in the maintenance of proper chromatin structure. NIPBL exists as three isoforms and is subject to DNA damage-dependent phosphorylation, probably by ATM or ATR. Mutations in the gene encoding NIPBL are the cause of Cornelia de Lange syndrome type 1 (CDLS1), a developmental disorder that is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation and various other malformations, including gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NIPBL of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of NIPBL of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of NIPBL of human origin |
| Entrez Gene | 25836 |
|---|
| Application Notes | recommended for detection of NIPBL of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
