Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing nuclear and cytoplasmic localization.| Product Name | Loricrin Antibody (W-22) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of Loricrin of human origin by WB, IP, IF, IHC(P) and ELISA |
| Modification Notes | Involucrin, Loricrin and Sciellin are components of the keratinocyte cornified envelope, which is formed beneath the inner surface of the cell membrane and replaces the plasma membrane during terminal differentiation. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. Loricrin localizes to the cytoplasm and the nucleus and is a substrate of transglutaminases. Mutations in LOR, the gene encoding Loricrin, may be involved in the skin disease loricrin keratoderma (LK), an ichthyotic variant of Vohwinkel syndrome (VS). LK is characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma. Clinical symptoms of LK include hyperkeratosis of the soles and palms along with digital constriction. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| WB:1:500~1:2000 IP:1:100~1:500 IF:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Loricrin of human origin by WB IP IF IHC(P) and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of Loricrin of human origin by WB, IP, IF, IHC(P) and ELISA |
| Entrez Gene | 4014 |
|---|
Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing nuclear and cytoplasmic localization.| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 IF:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
