Application
Western blot analysis of RBM38 expression in non-transfected: (A) and human RBM38 transfected: (B) 293T whole cell lysates.| Product Name | RBM38 Antibody (T-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of RBM38 of human origin |
| Modification Notes | Damage to nuclear DNA can lead to unregulated cell division and ultimately the formation of a cancerous tumor. Recognition and repair of damaged DNA is initiated by proteins, such as p53, that regulate the cell cycle. p53 is a transcription factor that induces cell cycle arrest at the G1/S regulation point when it functions to either activate repair proteins or initiate apoptosis. One protein induced by wildtype p53 is RBM38 (RNA-binding protein 38), also known as RNPC1 or SEB4. RBM38 is a cell cycle protein found in the cytosol and the nucleus that exists as two alternatively spliced isoforms, 1 (RNPC1a) and 2 (RNPC1b), of 239 and 121 amino acids, respectively. Independent of p53 expression, RBM38 isoform 1 induces cell cycle arrest in G1 phase through maintaining transcript stability at the 3’-UTR of p21, a regulator of cell cycle progression at S phase. RBM38 is also an mRNA splicing factor that regulates the expression of FGFR2. RBM38 contains one RRM (RNA recognition motif) domain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of RBM38 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other RBM family members also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of RBM38 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of RBM38 of human origin |
| Entrez Gene | 55544 |
|---|
Application
Western blot analysis of RBM38 expression in non-transfected: (A) and human RBM38 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of RBM38 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other RBM family members also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
