| Modification Notes |
OY-TES-1, also known as ACRBP (acrosin binding protein) or SP32, is a 543 amino acid secreted protein that is found on sperm acrosomes where it colocalizes with Acrosin. Expressed in normal testicular tissue, OY-TES-1 binds to Acrosin and is thought to mediate the packaging and condensation of Acrosin in the acrosomal matrix. In addition to its expression in testis, OY-TES-1 is present in cancer tissue throughout the body, including breast, bladder, liver and lung carcinomas, suggesting an involvement in tumor formation and metastasis. The gene encoding OY-TES-1 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders. |