| Product Name | Wnt-10a Antibody (H-77) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 153-229 mapping within an internal region of Wnt-10a of human origin |
| Modification Notes | The Wnt family of protooncogenes consists of at least 13 known members which encode secreted signaling proteins that are involved in oncogenesis and several other developmental processes, such as regulation of cell fate and embryogenesis. Wnt-10a (wingless-type MMTV integration site family, member 10A) is a 417 amino acid protein that is secreted into the extracellular matrix and belongs to the Wnt family. Strongly expressed in promyelocytic leukemia and Burkitt's lymphoma, Wnt-10a functions as a ligand for frizzled proteins and is thought to be involved in development of the central nervous system, probably acting as a signaling molecule. Overexpression of Wnt-10a is associated with the pathogenesis of various carcinomas, strongly suggesting a role for Wnt-10a in tumor development and metastasis. Defects in the gene encoding Wnt-10a are the cause of odonto-onycho-dermal dysplasia (OODD), a rare autosomal recessive disorder that is characterized by dry hair, onychodysplasia and hyperkeratosis of the skin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Wnt-10a of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 153-229 mapping within an internal region of Wnt-10a of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 153-229 mapping within an internal region of Wnt-10a of human origin |
| Entrez Gene | 80326 |
|---|
| Application Notes | recommended for detection of Wnt-10a of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
