| Modification Notes |
The armadillo (ARM) repeat family of proteins are related to the Drosophila melanogaster armadillo protein, a protein essential for wingless signal transduction. ARM proteins are involved in a variety of processes such as cell migration, cell proliferation, tissue maintenance and tumorigenesis, and they also function in signal transduction and the maintenance of overall cell structure. ARMC4 (Armadillo repeat-containing protein 4) is a 1044 amino acid protein that contains ten ARM repeats and one HEAT repeat. ARMC4 may possibly function as a regulator of ciliogenesis in airway epithelial cells and testis. The gene encoding ARMC4 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. |