Application
Western blot analysis of SARM expression in F9 (A) and Daudi (B) whole cell lysates and mouse testis tissue extract (C).| Product Name | SARM Antibody (C-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against a synthetic peptide within the C-terminus of SARM1 of human origin |
| Modification Notes | SARM (sterile alpha and TIR motif), also known as SAMD2, SARM1 or KIAA0524, is a 724 amino acid protein that localizes to the cytoplasm and contains one TIR domain and two sterile alpha motif (SAM) domains. Expressed predominately in liver and kidney and present at lower levels in placenta, SARM interacts with TICAM-1 and, via this interaction, blocks the transcriptional activation activity of TICAM-1 and functions as a negative regulator of Toll-like receptor signaling. Additionally, SARM is thought to be involved in innate immune responses and may also play a role in the negative regulation of NF˚B activation. SARM exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 17. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIP |
| recommended for detection of SARM of mouse and human origin by WB and IP: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against a synthetic peptide within the C-terminus of SARM1 of human origin |
|---|---|
| Tissue Specificity | raised against a synthetic peptide within the C-terminus of SARM1 of human origin |
| Entrez Gene | 23098 |
|---|
Application
Western blot analysis of SARM expression in F9 (A) and Daudi (B) whole cell lysates and mouse testis tissue extract (C).| Application Notes | recommended for detection of SARM of mouse and human origin by WB and IP: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
