| Product Name | DNA2L Antibody (N-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of DNA2L of human origin |
| Modification Notes | The replication of lagging strand DNA requires several enzymatic steps that eventually lead to the generation of Okazaki fragments; small DNA strands that are attached by DNA Ligase. DNA2L (DNA2-like helicase), also known as DNA2, is a 1,060 amino acid human homolog of yeast DNA2, a helicase/nuclease that is essential for genome stability and DNA metabolism. In yeast, DNA2 acts as a DNA-dependent ATPase that unwinds duplex DNA, thereby producing single-standed DNA that serves as a template for DNA replication. In humans, DNA2L functions as a helicase that is involved in DNA replication, DNA repair and chromatin dynamics. Specifically, DNA2L is thought to play a role in the maturation and elongation of Okazaki fragments, thereby facilitating replication of the lagging strand. Mutations in the gene encoding DNA2L are lethal, suggesting that proper DNA2L function is crucial for cell viability. Three isoforms of DNA2L exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of DNA2L of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with DNA2 also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of DNA2L of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of DNA2L of human origin |
| Entrez Gene | 1763 |
|---|
| Application Notes | recommended for detection of DNA2L of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with DNA2 also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
