| Product Name | FACE-1 Antibody (H-170) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-170 mapping at the N-terminus of FACE-1 of human origin |
| Modification Notes | FACE-1, or Zinc metalloproteinase Ste24 homolog (Zmpste24), is a metalloproteinase responsible for cleaving prelamin A to lamin A, a component of the nuclear envelope. An integral membrane protein, FACE-1 is widely expressed in tissues throughout the human body and uses zinc as a cofactor, with one zinc ion per subunit. Mutations in the FACE-1 gene are linked to laminopathies in humans, including restrictive dermopathy (RD) and mandibuloacral dysplasia (MAD), both characterized by severe developmental abnormalities and in the case of RD, early neonatal death. Accumulation of unprocessed prelamin A may be responsible for deficits associated with these genetic disorders. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FACE-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-170 mapping at the N-terminus of FACE-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-170 mapping at the N-terminus of FACE-1 of human origin |
| Entrez Gene | 10269 |
|---|
| Application Notes | recommended for detection of FACE-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
