| Product Name | NORRIN Antibody (FL-133) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-133 representing full length NORRIN of human origin |
| Modification Notes | The NDP (Norrie disease protein) gene encodes the secreted NORRIN protein. Mutations in this gene lead to Norrie disease, a rare X-linked disorder characterized by congenital blindness, deafness and mental retardation. X-linked familial exudative vitreoretinopathy (XL-FEVR), an ocular disorder characterized by a failure of peripheral retinal vascularization, is also associated with mutations in the NDP gene. NORRIN utilizes the Wnt/Frizzled signaling pathway and plays a role in vascular development. Research indicates that it induces growth of ocular capillaries and that pharmacologic regulation of NORRIN may be useful for treatment of the vascular abnormalities associated with Norrie disease or other vascular disorders of the retina. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NORRIN of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-133 representing full length NORRIN of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-133 representing full length NORRIN of human origin |
| Entrez Gene | 4693 |
|---|
| Application Notes | recommended for detection of NORRIN of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
