| Product Name | GPS2 Antibody (H-225) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 103-327 mapping at the C-terminus of GPS2 of human origin |
| Modification Notes | The N-Cor-HDAC3 repressor complex inhibits the JNK pathway, which is involved in cell differentiation and apoptosis and responds to stress stimuli. G protein pathway suppressor 2 (GPS2), also referred to as AMF1, is an integral component of the N-Cor-HDAC3 complex and functions to suppress G-protein and MAP kinase-mediated signal transduction. The N-Cor complex inhibits the JNK pathway, a pathway that is involved in cell differentiation and apoptosis and responds to stress stimuli. TBL1, another component of the complex, interacts with GPS2 to form a heterotrimeric structure. GPS2 can also stimulate the activity of cellular transcription factors including the human papilloma virus E2 and E6 proteins, as well as p53. Amplified expression of GPS2 may augment p53-dependent transcription, causing a G(1) arrest in cells. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of GPS2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 103-327 mapping at the C-terminus of GPS2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 103-327 mapping at the C-terminus of GPS2 of human origin |
| Application Notes | recommended for detection of GPS2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
