| Product Name | 17β-HSD2 Antibody (M-165) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 211-375 mapping near the C-terminus of 17β-HSD2 of mouse origin |
| Modification Notes | 17∫-HSD2 (17∫ hydroxysteroid dehydrogenase type 2) belongs to the 17∫-HSD family of proteins that regulate the availability of steroids within a tissue. 17∫-HSD2 converts active steroids to their inactive form through its oxidative activity. It is a key player in the inactivation of Estradiol and testosterone. Due to the affects that 17∫-HSD2 has on the availability of estrogen, it has been extensively investigated for playing a possible role in breast tumor development, colon cancer development and the pathophysiology of endometriosis. 17∫-HSD2 is predominantly expressed in the placenta, endometrium and prostate but can also be found in the liver, small intestine, and kidney. 17∫-HSD2 is a membrane bound protein. Tibolone, a treatment used for climacteric symptoms in menopausal women, functions in part by activating 17∫-HSD2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of 17β-HSD2 of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 211-375 mapping near the C-terminus of 17&beta -HSD2 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 211-375 mapping near the C-terminus of 17β-HSD2 of mouse origin |
| Application Notes | recommended for detection of 17β-HSD2 of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
