| Product Name | ADAMTS-L4 Antibody (H-250) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 586-835 mapping within an internal region of ADAMTS-L4 of human origin |
| Modification Notes | ADAMTS (A Disintegrin And Metalloproteinase Domain with Thrombospondin type 1 Modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of Thrombospondin type 1 (TSP-1) motifs. ADAMTS-L4 (ADAMTS-like protein 4), also known as TSRC1 (Thrombospondin repeat-containing protein 1), is a 1074 amino acid secreted protein. Known to interact with cathepsin B, ADAMTS-L4 functions as a positive regulator of apoptosis. Mutations in the gene that encodes ADAMTS-L4 are a cause of autosomal recessive isolated ectopia lentis (EL), a rare condition in which defective zonule formation results in partial or complete displacement of the lens from its space. ADAMTS-L4 is expressed in spleen, liver, skeletal muscle, lung, colon, testis, placenta heart and leukocyte. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ADAMTS-L4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 586-835 mapping within an internal region of ADAMTS-L4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 586-835 mapping within an internal region of ADAMTS-L4 of human origin |
| Application Notes | recommended for detection of ADAMTS-L4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
