| Product Name | Ganglioside sialidase Antibody (M-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 228-277 mapping within an internal region of Ganglioside sialidase of mouse origin |
| Modification Notes | Ganglioside sialidase is a 428 amino acid protein encoded by the human gene NEU3. Ganglioside sialidase is a peripheral membrane protein that belongs to the glycosyl hydrolase 33 family. Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes. The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. These repeats are found in a variety of non-homologous proteins, including bacterial ribonucleases, Reelin, netrins, sialidases, neuraminidases, and a variety of glycosyl hydrolases. Ganglioside sialidase plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. Ganglioside sialidase is responsible for the catalytic hydrolysis of a-glycosidic linkages on terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. Ganglioside sialidase is highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. It is weakly expressed in kidney, placenta, brain and lung. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Ganglioside sialidase of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 228-277 mapping within an internal region of Ganglioside sialidase of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 228-277 mapping within an internal region of Ganglioside sialidase of mouse origin |
| Application Notes | recommended for detection of Ganglioside sialidase of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
