| Product Name | ING2 Antibody (H-71) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ING2 (Inhibitor of growth protein 2, p33ING2) is a 280 amino acid protein encoded by the human gene ING2. ING2 belongs to the ING family and contains one PHD-type zinc finger. ING2 is believed to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. It is a component of a MSinA-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). ING2 is predominantly a nuclear protein that is localized to chromatin and the nuclear matrix. Upon reduced PtdIns(5)P levels, ING2 seems to be released from chromatin and, at least partially, translocated to the cytoplasm. ING2 is widely expressed with higher expression in colon-cancer tumor than in normal colon tissues. It can also be induced by the DNA-damaging agents etoposide and neocarzinostatin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of inhibitor of growth protein 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 111-181 mapping within an internal region of ING2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 111-181 mapping within an internal region of ING2 of human origin |
| Entrez Gene | 3622 |
|---|
| Application Notes | recommended for detection of inhibitor of growth protein 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
