Application
Western blot analysis of LXRα expression in non-transfected: (A) and human LXRα transfected: (B) 293T whole cell lysates.Application
Western blot analysis of LXRα expression in non-transfected: (A) and human LXRα transfected: (B) 293T whole cell lysates.Application
Western blot analysis of LXRα expression in non-transfected: (A) and mouse LXRα transfected: (B) 293T whole cell lysates.Application
Western blot analysis of LXRβ expression in non-transfected: (A) and human LXRβ transfected: (B) 293T whole cell lysates.Application
Western blot analysis of LXRβ expression in non-transfected: (A) and human LXRβ transfected: (B) 293T whole cell lysates.Application
Western blot analysis of LXRα/β expression in mouse liver tissue extract.| Product Name | LXRα/β Antibody (H-144) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Retinoids are metabolites of vitamin A (retinol) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. The cooperation of liver X receptors (LXRs) å and ∫ and retinoic X receptor (RXR) modulate the expression of several genes involved in lipid metabolism in hepatocyte and macrophages. RXR is the receptor for 9-cis retinoic acid and dimerizes with VDR, TR, PPAR and several novel receptors including liver X receptors LXRå (also referred to as RLD-1), LXR∫ and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. Both LXR/ RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. LXRå and LXR∫ share considerable sequence homology and several functions, respond to the same endogenous and synthetic ligands and play critical roles in maintaining lipid homeostasis. LXR∫ is ubiquitously expressed and enriched in tissues of neuronal and endocrine origin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISAGSChIP |
| recommended for detection of LXR&alpha and LXR&beta of mouse, rat and human origin by WB, IP and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 301-444 mapping at the C-terminus of LXR&alpha of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 301-444 mapping at the C-terminus of LXRα of human origin |
| Entrez Gene | 7376 |
|---|
Application
Western blot analysis of LXRα expression in non-transfected: (A) and human LXRα transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of LXRα expression in non-transfected: (A) and human LXRα transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of LXRα expression in non-transfected: (A) and mouse LXRα transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of LXRβ expression in non-transfected: (A) and human LXRβ transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of LXRβ expression in non-transfected: (A) and human LXRβ transfected: (B) 293T whole cell lysates.
Application
Western blot analysis of LXRα/β expression in mouse liver tissue extract.| Application Notes | recommended for detection of LXR&alpha and LXR&beta of mouse, rat and human origin by WB, IP and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
