| Product Name | PAO Antibody (H-85) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Mammalian polyamine catabolism is under the control of two enzymes, spermidine/spermine N1-acetyltransferase and the flavin adenine dinucleotide-dependent polyamine oxidase (PAO). In the polyamine back-conversion pathway, spermine and spermidine are acetylated by SSAT-1 and then oxidized by PAO to produce spermidine and putrescine, respectively. The PAO protein regulates polyamine intracellular concentration and may act as a determinant of cellular sensitivity to the antitumor polyamine analogs. PAO contributes to beta-alaline production via aldehyde dehydrogenase conversion of 3-amino-propanal. The PAO gene encodes more than five transcript variants which encode four active isoenzymes. The longest isoenzyme, PAOh1 represents a new addition to the polyamine metabolic pathway and may be a target for antineoplastic drug development . |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PAO1, 2, 4 and 5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 197-281 mapping within an internal region of PAO1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 197-281 mapping within an internal region of PAO1 of human origin |
| Entrez Gene | 54498 |
|---|
| Application Notes | recommended for detection of PAO1, 2, 4 and 5 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
