| Modification Notes |
RFPL1 and RFPL3 (ret finger protein-like 1 and 3), exist in a cluster of genes (along with RFPL2) which map to human chromosome 22q12.2-q13.3, sharing 95%-96% identity. RFPL1, 2 and 3, are thought to contribute to neocortex organization and size in primates, and show high expression in fetal neocortex and embryonic stem-cell neurogenesis. RFPL1 and RFPL3 genes encode two exons giving rise to putative RING-like motifs and B30-2 domains. RFPL1, also known as RNF78 or MGC132428, is a 317 amino acid protein known to have high expression in prostate with lower expression in adult brain, fetal liver and fetal kidney. The RFPL3 protein is 371 amino acids long and may have been emerged due to intrachromosomal duplication. |