| Modification Notes |
The human b-glucan protein (Dectin-1) is a small, type II transmembrane receptor that enables b-glucan-dependent, nonopsonic recognition of zymosan and other yeast-derived particles by primary macrophages. Dectin-1 is the human homolog of the C-type (calcium dependent) lectin-like receptor (CLEC) family that play an important role in regulating innate immunity. CLEC-1 is a 280 amino acid single-pass type II transmembrane protein expressed in dendritic and endothelial cells. It accumulates in perinuclear compartments and requires an associated chain to reach the cell surface. CLEC-1 is involved in antigen uptake and is homologous to the natural killer (NK) cell receptors, NKG2s and CD94, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. It has a single carbohydrate recognition domain with six conserved and two additional cysteine residues. Additionally, CLEC-1 has a cytoplasmic immuno-receptor tyrosine-based motif and many potential phosphorylation sites. |
