| Product Name | LRP1B Antibody (H-68) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRPs (low density lipoprotein related proteins), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, mediate the endocytosis of extracellular ligands. LRP1B is a member of the LRP subfamily that regulates the endocytic trafficking of the transmembrane protein beta-amyloid precursor protein (APP). Proteolytic processing of APP produces Amyloid-beta peptide (Abeta), a molecule that is involved in the pathogenesis of Alzheimer's disease. LRP1B also regulates the catabolism of the platelet derived growth factor (PDGF) beta-receptor, influencing the migration of smooth muscle cells, thereby implicating LRP1B in the development of atherosclerosis, a disease that affects the arterial blood vessel. LRP1B is also an important factor in the tumorgenesis of non-small cell lung cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LRP1B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 4381-4448 mapping near the C-terminus of LRP1B of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 4381-4448 mapping near the C-terminus of LRP1B of human origin |
| Entrez Gene | 53353 |
|---|
| Application Notes | recommended for detection of LRP1B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
