Vascular endothelial cell growth inhibitor (VEGI), also known as TNFRSF15 or TL1, is a member of the TNF superfamily. VEGI has a signaling pathway similar to TNF and is most likely a multifunctional cytokine. VEGI is found in brain, reproductive and late developmental stage embryonic tissues and is expressed predominantly in endothelial cells. It is an angiogenesis inhibitor of the TNF family and functions in part by directly inhibiting endothelial cell proliferation. VEGI may act as an autocrine factor to induce apoptosis in endothelial cells via activation of multiple signaling pathways, including stress protein kinases and certain caspases.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of VEGI of mouse, rat and human origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 1-174 representing full length VEGI of human origin
Tissue Specificity
epitope corresponding to amino acids 1-174 representing full length VEGI of human origin