DC-LAMP (DC-lysosome-associated membrane glycoprotein), also known as LAMP-3 (Lysosomal-associated membrane protein 3), TSC403 or CD208, is a 416 amino acid lysosome membrane protein that belongs to the LAMP family. DC-LAMP is expressed in lung, lymphoid organs and dendritic cells and is upregulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. It is suggested that DC-LAMP may be responsible for changing lysosomal function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. DC-LAMP is thought to play an important part in enhancing metastasic potential and may be a prognostic factor for cervical cancer.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of DC-LAMP of mouse and human origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 157-416 mapping at the C-terminus of DC-LAMP of human origin
Tissue Specificity
epitope corresponding to amino acids 157-416 mapping at the C-terminus of DC-LAMP of human origin