| Product Name | SERGEF Antibody (H-128) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | SERGEF (secretion-regulating guanine nucleotide exchange factor), also called DelGEF (deafness locus-associated putative guanine nucleotide exchange factor), is a guanine nucleotide exchange factor which is thought to be involved in secretion pathways. SERGEF associates with Sec5, a protein required for secretion, in a magnesium-dependent manner and is stimulated by the presence of deoxycytidine triphosphate (dCTP) or guanosine triphosphate (GTP). A homolog of RanGEF, SERGEF is localized to the nucleus and cytoplasm and is expressed throughout the body with high expression observed in the brain, placenta and skeletal muscle. SERGEF is a 458 amino acid protein which, upon DNA damage, is phosphorylated by Atm or ATR. Two isoforms exist due to alternative splicing. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SERGEF of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 17-144 mapping within an internal region of SERGEF of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 17-144 mapping within an internal region of SERGEF of human origin |
| Entrez Gene | 26297 |
|---|
| Application Notes | recommended for detection of SERGEF of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
