| Modification Notes |
Maltase-glucoamylase, also known as MGAM, MG or MGA, is a 1,857 amino acid multi-pass membrane protein that localizes to the apical cell membrane and contains two P-type domains. Expressed in kidney, small intestine and granulocytes, Maltase-glucoamylase exists as a monomer that is thought to participate in an alternate pathway of starch digestion, specifically when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. Maltase-glucoamylase is subject to post-translational N- and O-glycosylation, as well as sulfation. The gene encoding Maltase-glucoamylase maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. |