| Modification Notes |
SFI1, also known as PISD, is a 1242 amino acid protein belonging to the SFI1 family. Subcellularly localized to the centrosome, SFI1 interacts with Centrin-2 via a conserved Trp residue in the C-terminal end of SFI1. Via this interaction with Centrin-2, SFI1 plays a role in the dynamic structure of centrosome-associated contractile fibers. SFI1 also contains six HAT repeats, which may be involved in protein-protein interactions. SFI1 is expressed as seven isoforms produced by alternative splicing. SFI1 has been found to be expressed in brain, testis, uterus and lung. |