Application
Western blot analysis of HoxD11 expression in LNCaP (A) and SK-MEL-28 (B) whole cell lysates.| Product Name | HoxD11 Antibody (H-89) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 209-269 mapping within an internal region of HoxD11 of human origin |
| Modification Notes | The Hox proteins are a family of transcription factors that play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. Hox proteins are involved in controlling axial patterning, leukemias and hereditary malformations. HoxD11 (homeobox D11), also known as HOX4 or HOX4F, is a 338 amino acid protein that contains one homeobox DNA-binding domain and is a member of the Abd-B homeobox family. Localized to the nucleus, HoxD11 functions as a sequence-specific transcription factor that, in conjunction with a variety of other proteins, provides cells with positional identities on their anterior-posterior axis. Defects in the gene encoding HoxD11 are associated with severe limb and genital abnormalities, suggesting that HoxD11 plays an important role in forelimb morphogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of HoxD11 of mouse and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 209-269 mapping within an internal region of HoxD11 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 209-269 mapping within an internal region of HoxD11 of human origin |
| Entrez Gene | 3237 |
|---|
Application
Western blot analysis of HoxD11 expression in LNCaP (A) and SK-MEL-28 (B) whole cell lysates.| Application Notes | recommended for detection of HoxD11 of mouse and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
