recommended for detection of TTC19 of mouse and rat origin by WB, IP and ELISA
Modification Notes
The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that associates with other TPR repeats to achieve ligand binding specificity. TTC19 (tetratricopeptide repeat domain 19) is a 501 amino acid protein containing five TPR repeats. TTC19 is encoded be a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes, some of which are involved in tumor suppression and in the pathogenesis of Li-Fraumeni syndrome, early onset breast cancer and a predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
recommended for detection of TTC19 of mouse and rat origin by WB IP and ELISA
Tissue Specificity
recommended for detection of TTC19 of mouse and rat origin by WB, IP and ELISA